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Sildenafil is actually a powerful and selective inhibitor of cGMP unique phosphodiesterase type 5 (PDE5) within the corpus cavernosum, in which PDE5 is responsible for degradation of cGMP. Sildenafil has a peripheral internet site of action on erections. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently impro

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